They were strictly held apart by the Supreme Court’s 1896 Plessy v Ferguson decision.
Living with the aftereffect of a manic episode can be difficult to cope with. It alternates between depressions, long plateaus of a normal state, and sometimes a bright or manic effect, which may also be accompanied by psychosis, when the person acts in ways that do not resemble their character or values when properly medicated or in their right state of mind. Like all mental illnesses, bipolar can be difficult to live with.